The p53 tumour suppressor protein is a transcription factor that prevents oncogenic progression by activating the expression of apoptosis and cell-cycle arrest genes in stressed cells. The stability of p53 is tightly regulated by ubiquitin-dependent degradation. driven mainly by its negative regulators ubiquitin ligase MDM2. In this study. https://www.chiggate.com/elliot-pecan-tree-sale/